From Sample to Sequence: Immunopeptidomics on the Orbitrap Astral Mass Spectrometer

Immunopeptidomics is a cutting-edge field focused on identifying and characterizing peptides presented by major histocompatibility complex (MHC) Class I and II molecules on cell surfaces. These peptides are essential for immune recognition and antigen presentation, as they are recognized by T cell receptors. The study of MHC peptides is pivotal for various research areas, including immunotherapy and personalized medicine. Mass spectrometry (MS) is the cornerstone analytical technique in immunopeptidomics, uniquely capable of directly measuring and quantifying MHC peptide presentation across a vast array of targets.

 

We are excited to invite you to our upcoming webinar, where our distinguished speaker, Maria Wahle, will delve into the application of the Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer for immunopeptidomics analysis.

 

The Orbitrap Astral Mass Spectrometer offers a new level of depth in characterization of the immunopeptidome. This cutting-edge technology provides unmatched sensitivity in analysis and excels in handling samples of varying dynamic ranges. Whether working with low (ug) sample amounts, this platform ensures uncompromised, saturation-free analysis. Maria Wahle will share insights into the experimental methods her laboratory has developed to enable the efficient and high-throughput acquisition of immunopeptidomics samples. In addition, she will discuss advanced data analysis techniques and demonstrate their practical application to biological samples.

 

You will learn: