mouse monoclonal IgG2b; SKIP Antibody (B-6) is an IgG2b κ mouse monoclonal SKIP antibody (also designated SKIP antibody) that detects the SKIP protein of human origin by WB, IP, IF, IHC(P) and ELISA. SKIP Antibody (B-6) is available as both the non-conjugated anti-SKIP antibody form, as well as multiple conjugated forms of anti-SKIP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The inositol polyphosphate 5-phosphatases selectively remove the phosphate from the 5-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. SKIP (skeletal muscle and kidney enriched inositol phosphatase) is a Type II 5-phosphatase that contains two highly conserved catalytic motifs. It is predominantly expressed in skeletal muscle, heart, brain, and kidney, but can also be detected in some tissues as a shorter protein, which is produced by alternative splicing. SKIP has a high affinity for phosphatidylinositol 4,5-bisphosphate as a substrate as well as inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, and phosphatidylinositol 3,4,5-trisphosphate. SKIP is localized in the cytoplasm and at ruffling membranes. Cells expressing SKIP display a loss of actin stress fibers where the protein was localized, suggesting that SKIP plays a negative role in regulating the actin cytoskeletal structure.