mouse monoclonal IgG2b; NOSIP Antibody (C-2) is an IgG2b κ mouse monoclonal NOSIP antibody (also designated NOSIP antibody) that detects the NOSIP protein of mouse, rat and human origin by WB, IP, IF and ELISA. NOSIP Antibody (C-2) is available as both the non-conjugated anti-NOSIP antibody form, as well as multiple conjugated forms of anti-NOSIP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Endothelial nitric oxide synthase (eNOS) interacting protein (NOSIP) is a modulator of eNOS activity. eNOS is an important nitric oxide (NO)-generating enzyme of the vasculature that is regulated by interactions with caveolin-1, Ca2+-calmodulin, HSP 90 and NOSIP. NOSIP modulates this activity by promoting the translocation of eNOS from the plasma membrane to intracellular sites, which in turn inhibits NO synthesis. NOSIP is involved in controlling airway and vascular diameter, synthesis of NO in ciliated epithelia and mucosal secretion, and is an important protein for mucociliary and bronchial function. NOSIP is highly expressed in endothelial cells and vascularized tissue.